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연구성과 > HIGHLY CITED PAPERS (HCP)

  • 전임교원이 최근 5년간 출판한 논문 중, 연도별 카테고리별 피인용 상위 1%에 달성된 논문
  • 매월 1회 업데이트
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SCIE Article

[Excluded] Engineering of cell microenvironment-responsive polypeptide nanovehicle co-encapsulating a synergistic combination of small molecules for effective chemotherapy in solid tumors
Author Ramasamy, Thiruganesh; Ruttala, Hima Bindu; Chitrapriya, Nataraj; Poudal, Bijay Kumar; Choi, Ju Yeon; Kim, Ssang Tae; Youn, Yu Seok; Ku, Sae Kwang; Choi, Han-Gon; Yong, Chul Soon
Corresponding Author Info Prof. Choi, Han-Gon (최한곤 교수, 약학과)
Professor
E-mail 메일hangon@hanyang.ac.kr
Document Type
Source ACTA BIOMATERIALIA 2017, 48, 131-143
Times Cited Excluded
External Information pdfhttp://www.sciencedirect.com/science/article/pii/S1742706116305621
Abstract - 출판연도: JAN 15 2017

[History]
- 2018년 8월 13일 현재 HCP 리스트에서 제외되어 있습니다.
- 7월/8월 2017년 부로, 이 인용 빈도가 높은 논문의 인용 횟수가 분야와 출판 연도에 대해 Materials Science 관련 학술 분야에서 상위 1%에 올랐습니다.

[Abstract]
In this study, we report a facile method to construct a bioactive (poly(phenylalanine)-b-poly(t-histidine)-b-poly(ethylene glycol) polypeptide nanoconstruct to co-load doxorubicin (DOX) and quercetin (QUR) (DQ-NV). The smart pH-sensitive nanovehicle was fabricated with precisely tailored drug-to-carrier ratio that resulted in accelerated, sequential drug release. As a result of ratiometric loading, QUR could significantly enhance the cytotoxic potential of DOX, induced marked cell apoptosis; change cell cycle patterns, inhibit the migratory capacity of sensitive and resistant cancer cells. In particular, pro-oxidant QUR from DQ-NV remarkably reduced the GSH/GSSG ratio, indicating high oxidative stress and damage to cellular components. DQ-NV induced tumor shrinkage more effectively than the single drugs in mice carrying subcutaneous SCC-7 xenografts. DQ-NV consistently induced high &#101xpression of caspase-3 and PARP and low &#101xpression of Ki67 and CD31 immunomarkers. In summary, we demonstrate the development of a robust polypeptide-based intracellular nanovehicle for synergistic delivery of DOX/QUR in cancer chemotherapy.
Web of Science Categories Engineering, Biomedical; Materials Science, Biomaterials
Funding
Language
리스트
전체 Excluded 기타
이미지

Microalgae - A promising tool for heavy metal remediation

Author(s) : Kumar, K. Suresh; Shin, Kyung-Hoon

Source : ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY  2015, 113, 329-352

Time Cited : 243 (2020.09.21)

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Effect of supplementary cementitious materials on reduction of CO2 emissions from concrete

Author(s) : Yang, Keun-Hyeok; Jung, Yeon-Back; Cho, Myung-Sug; Tae, Sung-Ho

Source : JOURNAL OF CLEANER PRODUCTION  2015, 103, 774-783

Time Cited : 134 (2020.09.21)

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ENSO Atmospheric Teleconnections and Their Response to Greenhouse Gas Forcing

Author(s) : Yeh, Sang-Wook; Cai, Wenju; Min, Seung-Ki; McPhaden, Michael J.; Domme...

Source : REVIEWS OF GEOPHYSICS  2018, 56, 185-206

Time Cited : 90 (2020.09.21)

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Unveiling dual-linkage 3D hexaiminobenzene metal-organic frameworks towards long-lasting advanced reversible Zn-air batteries

Author(s) : Shinde, Sambhaji S.; Lee, Chi Ho; Jung, Jin-Young; Wagh, Nayantara K.;...

Source : ENERGY & ENVIRONMENTAL SCIENCE  2019, 12, 2, 727-738

Time Cited : 55 (2020.09.21)

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Unveiling dual-linkage 3D hexaiminobenzene metal-organic frameworks towards long-lasting advanced reversible Zn-air batteries

Author(s) : Shinde, Sambhaji S.; Lee, Chi Ho; Jung, Jin-Young; Wagh, Nayantara K.;...

Source : ENERGY & ENVIRONMENTAL SCIENCE  2019, 12, 2, 727-738

Time Cited : 55 (2020.09.21)

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[NEW] Incentive-based demand response for smart grid with reinforcement learning and deep neural network

Author(s) : Lu, Renzhi; Hong, Hong, Seung Ho;

Source : APPLIED ENERGY  2019, 236, 937-949

Time Cited : 35 (2020.09.21)

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[Excluded] An Incentive-Based Demand Response (DR) Model Considering Composited DR Resources

Author(s) : Yu, Mengmeng; Hong, Seung Ho; Ding, Yuemin; Ye, Xun

Source : IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS  2019, 66, 1488-1498

Time Cited : Excluded

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[Excluded] Combined effect of El Nino-Southern Oscillation and Pacific Decadal Oscillation on the East Asian winter monsoon

Author(s) : Kim, Ji-Won; Yeh, Sang-Wook; Chang, Eun-Chul

Source : CLIMATE DYNAMICS  2014, 42, 3-4, 957-971

Time Cited : Excluded

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[Excluded] Novel visible light active graphitic C3N4-TiO2 composite photocatalyst: Synergistic synthesis, growth

Author(s) : Sridharan, Kishore; Jang, Eunyong; Park, Tae Joo

Source : APPLIED CATALYSIS B-ENVIRONMENTAL  2013, 142, 718-728

Time Cited : Excluded

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[Excluded] Engineering of cell microenvironment-responsive polypeptide nanovehicle co-encapsulating a synergistic combination of small molecules for effective chemotherapy in solid tumors

Author(s) : Ramasamy, Thiruganesh; Ruttala, Hima Bindu; Chitrapriya, Nataraj; Poud...

Source : ACTA BIOMATERIALIA  2017, 48, 131-143

Time Cited : Excluded

이미지

[Excluded] Ag/Au/Polypyrrole Core-shell Nanowire Network for Transparent, Stretchable and Flexible Supercapacitor in Wearable Energy Devices

Author(s) : Moon, Hyunjin; Lee, Habeom; Kwon, Jinhyeong; Suh, Young Duk; Kim, Dong...

Source : SCIENTIFIC REPORTS  2017, 7, 41981

Time Cited : Excluded

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[Excluded] Reduced Harm or Another Gateway to Smoking? Source, Message, and Information Characteristics of E-Ci

Author(s) : Paek, Hye-Jin; Kim, Sookyong; Hove, Thomas; Huh, Jung Yoon

Source : JOURNAL OF HEALTH COMMUNICATION  2014, 19, 545-560

Time Cited : Excluded

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[Excluded] Emission of bisphenol analogues including bisphenol A and bisphenol F from wastewater treatment plan

Author(s) : Lee, Sunggyu; Liao, Chunyang; Song, Geum-Ju; Ra, Kongtae; Kannan, Kuru...

Source : CHEMOSPHERE  2015, 119, 1000-1006

Time Cited : Excluded

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