연구진흥

창의적인 신지식 창출과 산업계와의 협력적 네트워크 구축

HIGHLY CITED PAPERS (HCP)

  • 전임교원이 최근 5년간 출판한 논문 중, 연도별 카테고리별 피인용 상위 1%에 달성된 논문
  • 매월 1회 업데이트
SCIE Article
Overview of the Manufacturing Methods of Solid Dispersion Technology for Improving the Solubility of Poorly Water-Soluble Drugs and Application to Anticancer Drugs
Author
Tran, P; Pyo, YC; Kim, DH; Lee, SE; Kim, JK; Park, JS
Corresponding Author Info
Prof. Kim, jin ki (약학과 김진기 교수)
Professor
E-mail
이메일jinkikim@hanyang.ac.kr
Document Type
Source
PHARMACEUTICS 2019, 11, 132
Times Cited
188 (2024.01.31.)
External Information
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470797/
Abstract
- 7월/8월 2020부로, 이 인용 빈도가 높은 논문의 인용 횟수가 분야와 출판 연도에 대해 Pharmacology & Toxicology 관련 학술 분야에서 상위 1%에 올랐습니다.
- 출판연도: MAR 2019

<Abstract>
Approximately 40% of new chemical entities (NCEs), including anticancer drugs, have been reported as poorly water-soluble compounds. Anticancer drugs are classified into biologic drugs (monoclonal antibodies) and small molecule drugs (nonbiologic anticancer drugs) based on effectiveness and safety profile. Biologic drugs are administered by intravenous (IV) injection due to their large molecular weight, while small molecule drugs are preferentially administered by gastrointestinal route. Even though IV injection is the fastest route of administration and ensures complete bioavailability, this route of administration causes patient inconvenience to visit a hospital for anticancer treatments. In addition, IV administration can cause several side effects such as severe hypersensitivity, myelosuppression, neutropenia, and neurotoxicity. Oral administration is the preferred route for drug delivery due to several advantages such as low cost, pain avoidance, and safety. The main problem of NCEs is a limited aqueous solubility, resulting in poor absorption and low bioavailability. Therefore, improving oral bioavailability of poorly water-soluble drugs is a great challenge in the development of pharmaceutical dosage forms. Several methods such as solid dispersion, complexation, lipid-based systems, micronization, nanonization, and co-crystals were developed to improve the solubility of hydrophobic drugs. Recently, solid dispersion is one of the most widely used and successful techniques in formulation development. This review mainly discusses classification, methods for preparation of solid dispersions, and use of solid dispersion for improving solubility of poorly soluble anticancer drugs.
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