연구진흥

창의적인 신지식 창출과 산업계와의 협력적 네트워크 구축

HIGHLY CITED PAPERS (HCP)

  • 전임교원이 최근 5년간 출판한 논문 중, 연도별 카테고리별 피인용 상위 1%에 달성된 논문
  • 매월 1회 업데이트
SCIE Article
Overview of the Manufacturing Methods of Solid Dispersion Technology for Improving the Solubility of Poorly Water-Soluble Drugs and Application to Anticancer Drugs
Author
Tran, P; Pyo, YC; Kim, DH; Lee, SE; Kim, JK; Park, JS
Corresponding Author Info
Prof. Kim, jin ki
Professor
E-mail
이메일jinkikim@hanyang.ac.kr
Document Type
Source
PHARMACEUTICS 2019, 11, 132
Times Cited
134 (2023.03.10)
External Information
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470797/
Abstract
- 7월/8월 2020부로, 이 인용 빈도가 높은 논문의 인용 횟수가 분야와 출판 연도에 대해 Pharmacology & Toxicology 관련 학술 분야에서 상위 1%에 올랐습니다.
- 출판연도: MAR 2019

<Abstract>
Approximately 40% of new chemical entities (NCEs), including anticancer drugs, have been reported as poorly water-soluble compounds. Anticancer drugs are classified into biologic drugs (monoclonal antibodies) and small molecule drugs (nonbiologic anticancer drugs) based on effectiveness and safety profile. Biologic drugs are administered by intravenous (IV) injection due to their large molecular weight, while small molecule drugs are preferentially administered by gastrointestinal route. Even though IV injection is the fastest route of administration and ensures complete bioavailability, this route of administration causes patient inconvenience to visit a hospital for anticancer treatments. In addition, IV administration can cause several side effects such as severe hypersensitivity, myelosuppression, neutropenia, and neurotoxicity. Oral administration is the preferred route for drug delivery due to several advantages such as low cost, pain avoidance, and safety. The main problem of NCEs is a limited aqueous solubility, resulting in poor absorption and low bioavailability. Therefore, improving oral bioavailability of poorly water-soluble drugs is a great challenge in the development of pharmaceutical dosage forms. Several methods such as solid dispersion, complexation, lipid-based systems, micronization, nanonization, and co-crystals were developed to improve the solubility of hydrophobic drugs. Recently, solid dispersion is one of the most widely used and successful techniques in formulation development. This review mainly discusses classification, methods for preparation of solid dispersions, and use of solid dispersion for improving solubility of poorly soluble anticancer drugs.
Web of Science Categories
PHARMACOLOGY PHARMACY
Funding
Language
ENSO Atmospheric Teleconnections and Their Response to Greenhouse Gas Forcing
  • Author(s)
    Yeh, Sang-Wook; Cai, Wenju; Min, Seung-Ki; McPhaden, Michael J.; Domme...
  • Source
    REVIEWS OF GEOPHYSICS 2018, 56, 185-206
  • Time Cited
    236 (2023.03.10)
Unveiling dual-linkage 3D hexaiminobenzene metal-organic frameworks towards long-lasting advanced reversible Zn-air batteries
  • Author(s)
    Shinde, Sambhaji S.; Lee, Chi Ho; Jung, Jin-Young; Wagh, Nayantara K.;...
  • Source
    ENERGY & ENVIRONMENTAL SCIENCE 2019, 12, 2, 727-738
  • Time Cited
    212 (2023.03.10)
Overview of the Manufacturing Methods of Solid Dispersion Technology for Improving the Solubility of Poorly Water-Soluble Drugs and Application to Anticancer Drugs
  • Author(s)
    Tran, P; Pyo, YC; Kim, DH; Lee, SE; Kim, JK; Park, JS
  • Source
    PHARMACEUTICS 2019, 11, 132
  • Time Cited
    134 (2023.03.10)
Design of highly porous SnO2-CuO nanotubes for enhancing H2S gas sensor performance
  • Author(s)
    Park, Kee-Ryung; Cho, Hong-Baek; Lee, Jimin; Song, Yoseb; Kim, Woo-Byo...
  • Source
    SENSORS AND ACTUATORS B-CHEMICAL Sensors & Actuators: B. Chemical 302 (2020) 127179
  • Time Cited
    119 (2023.03.10)
Small extracellular vesicles from human adipose-derived stem cells attenuate cartilage degeneration
  • Author(s)
    Woo, Chang Hee; Kim, Hark Kyun; Jung, Gun Young; Jung, Youn Jae; Lee, ...
  • Source
    JOURNAL OF EXTRACELLULAR VESICLES 2020, 9, 1, 1735249
  • Time Cited
    103 (2023.03.10.)
Ruthenium Complexes as Anticancer Agents: A Brief History and Perspectives
  • Author(s)
    Lee, Sang Yeul; Kim, Chul Young; Nam, Tae-Gyu
  • Source
    DRUG DESIGN DEVELOPMENT AND THERAPY 2020, 14, 5375-5392
  • Time Cited
    80 (2023.03.10)
In-situ reconstructed Ru atom array on alpha-MnO2 with enhanced performance for acidic water oxidation
  • Author(s)
    Lin, Chao; Li, Ji-Li; Li, Xiaopeng; Yang, Shuai; Luo, Wei; Zhang, Yaoj...
  • Source
    NATURE CATALYSIS 2021, 4 1012-1023
  • Time Cited
    78 (2023.03.10)
Fabrication of hierarchically porous structured PDMS composites and their application as a flexible capacitive pressure sensor
  • Author(s)
    Hwang, Juwon; Kim, Yeongjun; Yang, Hyeondong; Oh, Je Hoon
  • Source
    COMPOSITES PART B-ENGINEERING 2022-04-15
  • Time Cited
    75(2023.03.10.)
Ampere-hour-scale zinc-air pouch cells
  • Author(s)
    Shinde, SS; Jung, JY; Wagh, NK; Lee, CH; Kim, DH; Kim, SH; Lee, SU; Le...
  • Source
    NATURE ENERGY 2021. 6.
  • Time Cited
    75 (2023.03.10.)
Reversible disorder-order transitions in atomic crystal nucleation
  • Author(s)
    Jeon, Sungho; Heo, Taeyeong; Hwang, Sang-Yeon; Ciston, Jim; Bustillo, ...
  • Source
    Science 2021, 371, 6528, 498
  • Time Cited
    58 (2023.03.10.)
Enhanced Chemodynamic Therapy by Cu-Fe Peroxide Nanoparticles: Tumor Microenvironment-Mediated Synergistic Fenton Reaction
  • Author(s)
    Koo, Sagang; Park, Ok Kyu; Kim, Jonghoon; Han, Sang Ihn; Yoo, Tae Yong...
  • Source
    ACS NANO 2022, 16, 2535-2545
  • Time Cited
    29 (2023.03.10)
Emerging approaches in lignocellulosic biomass pretreatment and anaerobic bioprocesses for sustainable biofuels production
  • Author(s)
    Kumar, Ramesh; Kim, Tae Hyun; Basak, Bikram; Patil, Swapnil M.; Kim, H...
  • Source
    JOURNAL OF CLEANER PRODUCTION
  • Time Cited
    21 (2023.03.10)
A review on physico-chemical delignification as a pretreatment of lignocellulosic biomass for enhanced bioconversion
  • Author(s)
    Jamaldheen, Sumitha Banu; Kurade, Mayur B.; Basak, Bikram; Yoo, Chang ...
  • Source
    BIORESOURCE TECHNOLOGY 2022, 346, 12651
  • Time Cited
    21 (2023.03.10)
Single-cell analysis of gastric pre-cancerous and cancer lesions reveals cell lineage diversity and intratumoral heterogeneity
  • Author(s)
    Kim, J; Park, C; Kim, KH; Kim, EH; Kim, H; Woo, JK; Seong, JK; Nam, KT...
  • Source
    NPJ PRECISION ONCOLOGY 2022, 9
  • Time Cited
    15 (2023.03.10)
Cilostazol-loaded solid lipid nanoparticles: Bioavailability and safety evaluation in an animal model
  • Author(s)
    Bibi, M; Din, FU; Anwar, Y; Alkenani, NA; Zari, AT; Mukhtiar, M; Abu Z...
  • Source
    JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY 2022, 74, 103581
  • Time Cited
    14 (2023.03.10
Scalable 3-D Carbon Nitride Sponge as an Efficient Metal-Free Bifunctional Oxygen Electrocatalyst for Rechargeable Zn-Air Batteries
  • Author(s)
    Shinde, Sambhaji; Lee, Chi-Ho; Sami, Abdul; Kim, Dong-Hyung; Lee, Sang...
  • Source
    ACS NANO 2017, 11, 1, 347-357
  • Time Cited
    excluded
Scalable 3-D Carbon Nitride Sponge as an Efficient Metal-Free Bifunctional Oxygen Electrocatalyst for Rechargeable Zn-Air Batteries
  • Author(s)
    Shinde, Sambhaji; Lee, Chi-Ho; Sami, Abdul; Kim, Dong-Hyung; Lee, Sang...
  • Source
    ACS NANO 2017, 11, 1, 347-357
  • Time Cited
    excluded
[Excluded]Online Control of Preamble Groups With Priority in Massive IoT Networks
  • Author(s)
    Liu, Jie (Dept Elect & Elect Engn); Hu Jin (Dept Elect & Elect Engn) ...
  • Source
    IEEE JOURNAL ON SELECTED AREAS IN COMMUNICATIONS Volume:39 Issue:3 Pages:700-713 Published:2021
  • Time Cited
    Excluded
[Excluded] Inorganic nanoparticles with enzyme-mimetic activities for biomedical applications
  • Author(s)
    Lakshminarayana, G.; Kebaili, Imen; Dong, M. G.; Al-Buriahi, M. S.; Da...
  • Source
    COORDINATION CHEMISTRY REVIEWS 403 (2020) 213092
  • Time Cited
    Excluded
[Excluded]Estimation of gamma-rays, and fast and the thermal neutrons attenuation characteristics for bismuth tellurite and bismuth boro-tellurite glass systems
  • Author(s)
    Lakshminarayana, G; Kebaili, I; Dong, MG; Al-Buriahi, MS; Dahshan, A; ...
  • Source
    JOURNAL OF MATERIALS SCIENCE J Mater Sci (2020) 55:5750–5771
  • Time Cited
    Excluded