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창의적인 신지식 창출과 산업계와의 협력적 네트워크 구축

HIGHLY CITED PAPERS (HCP)

  • 전임교원이 최근 5년간 출판한 논문 중, 연도별 카테고리별 피인용 상위 1%에 달성된 논문
  • 매월 1회 업데이트
SCIE Article
Enhanced Chemodynamic Therapy by Cu-Fe Peroxide Nanoparticles: Tumor Microenvironment-Mediated Synergistic Fenton Reaction
Author
Koo, Sagang; Park, Ok Kyu; Kim, Jonghoon; Han, Sang Ihn; Yoo, Tae Yong; Lee, Nohyun; Kim, Young Geon; Kim, Hyunjoong; Lim, Chaehong; Bae, Jong-Seong; Yoo, Jin; Kim, Dokyoon; Choi, Seung Hong; Hyeon, Taeghwan
Corresponding Author Info
Prof. Kim Dokyoon(생명나노공학과 김도균 교수)
Professor
E-mail
이메일kimdk@hanyang.ac.kr
Document Type
Source
ACS NANO 2022, 16, 2535-2545
Times Cited
101 (2024.01.31.)
External Information
http://dx.doi.org/10.1021/acsnano.1c09171
Abstract
[History]
- 9월/10월 2022부로, 이 인용 빈도가 높은 논문의 인용 횟수가 분야와 출판 연도에 대해 Materials Science 관련 학술 분야에서 상위 1%에 올랐습니다.

[Abstract]
An urgent need in chemodynamic therapy (CDT) is to achieve high Fenton catalytic efficiency at small doses of CDT agents. However, simple general promotion of the Fenton reaction increases the risk of damaging normal cells along with the cancer cells. Therefore, a tailored strategy to selectively enhance the Fenton reactivity in tumors, for example, by taking advantage of the characteristics of the tumor microenvironment (TME), is in high demand. Herein, a heterogeneous CDT system based on copper-iron peroxide nanoparticles (CFp NPs) is designed for TME-mediated synergistic therapy. CFp NPs degrade under the mildly acidic conditions of TME, self-supply H2O2, and the released Cu and Fe ions, with their larger portions at lower oxidation states, cooperatively facilitate hydroxyl radical production through a highly efficient catalytic loop to achieve an excellent tumor therapeutic efficacy. This is distinct from previous heterogeneous CDT systems in that the synergism is closely coupled with the Cu+-assisted conversion of Fe3+ to Fe2+ rather than their independent actions. As a result, almost complete ablation of tumors at a minimal treatment dose is demonstrated without the aid of any other therapeutic modality. Furthermore, CFp NPs generate O-2 during the catalysis and exhibit a TME-responsive T-1 magnetic resonance imaging contrast enhancement, which are useful for alleviating hypoxia and in vivo monitoring of tumors, respectively.
Web of Science Categories
Chemistry; Science & Technology - Other Topics; Materials Science
Funding
Language
English
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