연구진흥

창의적인 신지식 창출과 산업계와의 협력적 네트워크 구축

HIGHLY CITED PAPERS (HCP)

  • 전임교원이 최근 5년간 출판한 논문 중, 연도별 카테고리별 피인용 상위 1%에 달성된 논문
  • 매월 1회 업데이트
SCIE Article
Cilostazol-loaded solid lipid nanoparticles: Bioavailability and safety evaluation in an animal model
Author
Bibi, M; Din, FU; Anwar, Y; Alkenani, NA; Zari, AT; Mukhtiar, M; Abu Zeid, IM; Althubaiti, EH; Nazish, H; Zeb, A; Ullah, I; Khan, GM; Choi, HG
Corresponding Author Info
Prof. Choi, Han-gon(약학과 최한곤 교수)
Professor
E-mail
이메일hangon@hanyang.ac.kr
Document Type
Source
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY 2022, 74, 103581
Times Cited
14 (2023.03.10
External Information
http://dx.doi.org/10.1016/j.jddst.2022.103581
Abstract
[History]
- 이 화제의 논문은(는) 지난 2년간 출판되었으며, Geosciences 관련 학술 분야의 논문 중 상위 0.1%에 오를 수 있을 만큼 많이 3월/4월 2019에서 인용되었습니다.
- 11월/12월 2022부로, 이 인용 빈도가 높은 논문의 인용 횟수가 분야와 출판 연도에 대해 harmacology & Toxicology 관련 학술 분야에서 상위 1%에 올랐습니다.

[Abstract]
Cilostazol (CLZ) is an antiplatelet agent with limited solubility (similar to 6 mu g/ml at 25 degrees C), poor absorption and low oral bioavailability. In this study, solid lipid nanoparticles (SLNs) were used as a drug delivery system to improve the CLZ dissolution, absorption and bioavailability. Micro-emulsion method was used to fabricate CLZ-loaded SLNs. The SLNs were composed of palmityl alcohol, Tween (R) 80, and Span (R) 40 as solid lipid, surfactant, and co-surfactant, respectively. Additionally, Myrj 52 was used as a steric stabiliser. The SLNs were characterised in terms of particle size, zeta potential, polydispersity index (PDI), and incorporation efficiency (IE). Transmission electron microscopy (TEM), powder X-ray diffraction (PXRD), and Fourier transform infrared (FTIR) spectroscopy were also performed. In vitro release and pharmacokinetic studies were carried out, followed by evaluation of the safety and stability of the formulated SLNs. Optimised CLZ-loaded SLNs showed a spherical morphology with particle sizes below 200 nm, with excellent PDI (0.18), zeta potential (-29.7 mV), and %IE (92%). FTIR and PXRD studies indicated no chemical interaction between the constituents of the SLNs and the conversion of crystalline form of drug to amorphous form, respectively. CLZ-loaded SLNs demonstrated a significantly enhanced release (p < 0.05) and meaningfully improved bioavailability (p < 0.05) as compared with the CLZ suspension. Histopathological evaluation showed that CLZ-loaded SLNs were nontoxic to the cells lining the intestinal tract. They were found to have a stable shelf life during the three-month evaluation period. Hence, it was concluded that CLZ-loaded SLNs have the potential to improve the oral bioavailability of CLZ without toxicity.
Web of Science Categories
Pharmacology & Pharmacy
Funding
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